Regan's firing comes less than a month after Murdoch's cancellation of Simpson's hypothetical murder confession, "If I Did It," a planned book and Fox television interview that was greeted with instant and near-universal disgust when announced.
An industry force since the 1980s, when she produced best-sellers by Drew Barrymore and Kathie Lee Gifford for Simon & Schuster, Regan has been labeled a "foul-mouthed tyrant" and the "enfant terrible of American publishing." She is also widely envied - if not admired - for her gift of attracting attention to her books and to herself.
Since 1994, she has headed the ReganBooks imprint at News Corp.'s HarperCollins, an ideal fit for Murdoch's tabloid tastes. Regan has published a long list of racy best-sellers, including Jose Canseco's "Juiced" and Jenna Jameson's "How to Make Love Like a Porn Star," and is the rare publisher of interest to gossip columnists, notably for a rumored affair with former New York City Police Commissioner Bernard Kerik.
She often clashed with her more temperate peers and is widely believed to have had tense relations with Friedman. Last year, Regan moved her offices to Los Angeles, further distancing herself from corporate officials in New York.
Regan has often complained that her more literary side has been overlooked, pointing out that she has published books by Wally Lamb, Douglas Coupland and novelist Jess Walter, whose "The Zero" was a finalist for the National Book Award in November. The Simpson project, announced the day before the awards ceremony, quickly overshadowed the nomination.